HPLC CHROMATOGRAPHY HINTS and TIPS FOR CHROMATOGRAPHERS [HPLC TRAINING ARTICLES]

The HPLC "Hints and Tips" found here will be of interest to anyone performing HPLC, UHPLC (UPLC), LC/MS, SFC, CE or GC analysis. Many of these free tips, taken from professional classes that I teach, discuss fundamental to advanced level chromatography concepts in a practical way. Occasionally, I will also include laboratory computer related tips here too. Please "follow" this blog to receive updates of new posts. Hint: Type keywords into the SEARCH bar to quickly find other articles.

Showing posts with label Drift. Show all posts
Showing posts with label Drift. Show all posts
Saturday, February 10, 2018

HPLC Baseline Stabilization Tips for Refractive Index Detectors (RI or RID)

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If you use refractive index detection (RID) for your HPLC samples, then you are already familiar with the very long equilibration periods ne...
Saturday, March 4, 2017

The Three Most Common HPLC Questions and How To Solve Them

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The three most common HPLC related questions I am asked each week can be summarized below. Test your basic chromatography knowledge. Before...
Saturday, November 28, 2015

HPLC Retention Time Drift, Change, Area Variability or Poor Reproducibility. Common Reasons for it.

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Retention times and area measurements must be reproducible from run to run. When problems are observed, late, early or variable retention t...
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Saturday, September 6, 2014

Common Causes of Baseline Noise in HPLC, UHPLC.

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Achieving a flat baseline which does not exhibit spikes, ghost peaks, drift or wander in an unpredictable manner should be a primary ...
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HPLC EXPERT
AKA: "The HPLC Doctor". An expert Chromatographer, Scientist, Consultant and Inventor who works in the Analytical, BioMedical, BioPharma, Medicinal Chemistry, Medical Device and Product Engineering fields. I enjoy teaching, working with and training scientists to use different types of analytical instrumentation to solve challenging problems.
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